A Case Report of a Malignant Triton Tumor of the Left Retroperitoneum in a Young Female Without Neurofi bromatosis

Dayton Grogan BS, Vamsi Reddy BS*, Earl Dane Jones and Cargill H Alleyne

Malignant peripheral nerve sheath tumors (MPNST) are malignant cancers with origins found within peripheral nerves of various body regions-most commonly involving the buttocks, thighs, brachial plexus and para-spinal region [1]. While MPNSTs account for only 5%-10% of all soft tissue sarcomas, there exist MPNST variations that occur with greater rarity [2]. Specifi cally, Malignant Triton Tumors (MTT) are a subset of MPNST with rhabdomyoblastic differentiation and account for only 5% of all MPNST cases [3]. MTTs were fi rst described by Mason in 1932 and found to occur in patients with Neurofi bromatosis type 1 (NF-1) in slightly more than 50% of cases. This is because sMTTs are believed to originate from Schwann cells of peripheral nerves or within existing neurofi bromas [3,4]. Diagnosis of MTT is confi rmed by immunohistochemical screening for desmin, vimentin, actin, myoglobulin, and S-100 protein.

Keywords:

Published on: Sep 20, 2019 Pages: 14-16

Full Text PDF Full Text HTML DOI: 10.17352/2640-7876.000016
CrossMark Publons Harvard Library HOLLIS Search IT Semantic Scholar Get Citation Base Search Scilit OAI-PMH ResearchGate Academic Microsoft GrowKudos Universite de Paris UW Libraries SJSU King Library SJSU King Library NUS Library McGill DET KGL BIBLiOTEK JCU Discovery Universidad De Lima WorldCat VU on WorldCat