The finding that enzymes of purine metabolism interfere to the regulation of immune events is known from the findings of Giblett, et al. [1], that Adenosine Deaminase (ADA) deficiency leads to Severe Combined Immunbodeficiency (SCID), The same author described in 1975 case of T-immune deficiency caused by a deficiency of another purine metabolism enzyme - Purine Nucleoside Phosphorylase (PNP). Subsequently, otherl authors have described cases of hypo to agammaglobulinemia with 5´-nucleotidase (5-NT) deficiency in adults [2] and children [3].
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Published on: Sep 1, 2020 Pages: 200-201
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DOI: 10.17352/2455-5479.000106
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